History of Drug Use

At first, the use of drugs from plants is done empirically, based solely on experience and further Paracelsus (1541-1493 BC) found the drug to make the necessary preparations knowledge of active substance and he made ​​a drug made ​​from the known active substance. Hippocrates (459-370 BC), known as the "father of medicine" in the treatment practices have been used more than 200 species of plants. Claudius Galen (200-129 BC) linking labor theory of healing diseases with drugs that are pharmacologically science. Furthermore Ibn Sina (980-1037) has written several books on methods of collection and storage of medicinal plants as well as a way of making such dosage pills, suppositories, syrups and treatments combine knowledge from different countries, namely Greece, India, Persia, and Arabia to produce treatment better.
Wepfer Johann Jakob (1620-1695) succeeded in verifying the pharmacological and toxicological effects of drugs in experimental animals, he said: "I pondered at length, I finally resolved to clarify the matter by experiment". He was the first to conduct pharmacology and toxicology studies in animals. Experiments on animals is a preclinical test that until now was required before the drug was clinically tested in humans.
Institute of Pharmacology th first established in 1847 by Rudolf Buchheim (1820-1879) at the University of Dorpat (Estonia). Furthermore Schiedeberg Oswald (1838-1921) along with other disciplines experts produce the fundamental concepts of drug action include drug receptors, the structure activity relationships and selective toxicity. The concept is also reinforced by T. Frazer (1852-1921) in Scotland, J. Langley (1852-1925) in England and P. Ehrlich (1854-1915) in Germany.